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Diverse compounds mimic Alzheimer disease - causing mutations by augmenting Abeta42 production

Article Abstract:

A number of compounds that raise Abeta42, which is linked to the development of Alzheimer disease, are identified. Some of the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective nonsteroidal anti-inflammatory drug (NSAID).

Author: Koo, Edward H., Weggen, Sascha, Eriksen, Jason L., Sagi, Sarah A., Smith, Tawnya E., Golde, Todd E., Kukar, Thomas, Murphy, Michael Paul, Ladd, Thomas, Khan, Murad A., Kache, Rajashaker, Beard, Jenny, Dodson, Mark, Merit, Sami, Ozols, Victor V., Anastasiadis, Panos Z., Das, Pritam, Fauq, Abdul
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
United States, Science & research, Alzheimer's disease, Celecoxib

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Anti-cancer activity of targeted pro-apoptotic peptides

Article Abstract:

Researchers have developed a pro-apoptotic peptide that targets new blood vessels produced by tumors and destroys them by disrupting mitochondrial membranes. The peptide is non-toxic outside of cells but induces cell death when internalized.

Author: Ellerby, Lisa M., Bredesen, Dale E., Pasqualini, Renata, Arap, Wadih, Ruoslahti, Erkki, Krajewski, Stanislaw, Ellerby, H. Michael, Kain, Renate, Andrusiak, Rebecca, Del Rio, Gabriel, Lombardo, Christian R., Rao, Rammohan
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Prevention, Antineoplastic agents, Neovascularization, Cancer regression

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

Article Abstract:

Researchers describe a peptide unrelated to beta amyloid that is produced from amyloid beta-protein precursor. It is produced by caspases and induces neuronal cell death.

Author: Lu, Daniel C., Rabizadeh, Shahrooz, Chandra, Sreeganga, Shayya, Rana F., Ellerby, Lisa M., Ye, Xin, Salvesen, Guy S., Koo, Edward H., Bredesen, Dale E.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Identification and classification, Peptides

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Subjects list: Research, Causes of, Amyloid beta-protein, Cell death
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