Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years

Article Abstract:

There have been a variety of side effects from use of sulphasalazine (SSZ) or auranofin (AUR) over years of testing their effects on treatment of rheumatoid arthritis, but there has not been any case of systemic lupus erythematosus (SLE) connected with the use of these drugs, particularly in the five years of a current study. During that time patients who were taking either AUR or SSZ stopped because of rashes, mouth ulcers, leucopenia (which resolved immediately on stopping drug use). Also, some patients became positive for antinuclear antibodies (ANA) but presence of ANA is common in treatment of rheumatoid arthritis and none withdrew because of the rise in ANA.

Causes of, Complications and side effects, Sulfasalazine, Antinuclear antibodies, Auranofin

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Shrinking central nervous system in systemic lupus erythematosus

Article Abstract:

A 22-year-old patient suffering is examined due to the weakness in her legs and bladder dysfunction. She is diagnosed with neuropsychiatric manifestations of systemic lupus erythematosus; her entire case study is discussed.

United States, Case studies, Central nervous system, Neuropsychiatry

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Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

Article Abstract:

The results of the study to examine serum mannose binding lectin concentration before and after immunosuppressive treatment in patients with newly diagnosed systemic lupus erythematosus are presented.

Japan, Lectins

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