Drug shows promise for Marfan syndrome

Article Abstract:

A team of scientists at John Hopkins University has found that treatment with losartan prevented the development of aortic aneurysm and other defects in a mouse model of Marfan syndrome. In 1991 it was discovered that mutations in the gene that encodes fibrillin-1 cause Marfan syndrome and patients with this disorder have characteristics like long bone overgrowth or heart valve thickening.

Health aspects, Causes of, Drug therapy, Aortic aneurysms, Aortic aneurysm, Losartan, Disease/Disorder overview

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The gut yields clues to obesity, therapies

Article Abstract:

Gut hormones play a crucial role in regulating appetite and body weight and help in solving the problem of obesity. Research conducted on gut hormones highlights the role of such hormones in maintaining energy balance and how they might be exploited for the development of obesity treatments, as the organ has a highly redundant system of endocrine and neurological signals.

Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Hormones & Related Preparations, Hormone Preparations, Research, Obesity, Hormones

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Genes help unravel Marfan pathology, point way to potential new therapies

Article Abstract:

Modern genetic techniques are providing new insights into the pathogenesis of Marfan syndrome, a genetic disease causing skeletal malformations and abnormal conditions of the heart and other organs. Long-standing beliefs about this disease and associated disorders are being questioned by this increasing knowledge, which also paves the way for improved future therapies.

Care and treatment, Risk factors

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