Efavirenz as a substitute for protease inhibitors in HIV-1-infected patients with undetectable plasma viral load on HAART: a median follow-up of 64 weeks

Article Abstract:

Switching HIV patients from a protease inhibitor to efavirenz can maintain viral suppression with fewer side effects, according to a study of 62 patients. This may make it easier for patients to comply with the treatment.

Evaluation, Anti-HIV agents

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Tolerance of a short course of nevirapine, associated with 2 nucleoside analogues, in postexposure prophylaxis of HIV

Article Abstract:

A study was conducted with the aim of evaluating the tolerance of all nevirapine (NVP) containing postexposure prophylaxis (PEP) treatments prescribed during a 2-year period. The study gave evidence to believe that a short course of 200-mg NVP treatment once a day in combination with nucleoside analogues for one month is clinically and biologically safe.

United States, Science & research, Research, Dosage and administration, Nevirapine, Prophylaxis

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Virologic response of zidovudine, lamivudine, and tenofovir disoproxil fumarate combination in antiretroviral-naive HIV-1-infected patients

Article Abstract:

A pilot study was conducted to evaluate the immunovirologic efficacy of a new triple-nucleoside reverse transcriptase inhibitor (NRTI) combinations containing zidovudine (ZDV), lamivudine (3TC), and tenofovir disoproxil fumarate (TDF) in ARV-naive HIV-1-infected patients. It is concluded that the combination of ZDV/3TC + TDF in treatment-naive HIV-infected subjects induces a rapid and sustained HIV-1 RNA decrease and is associated with a good immunologic response.

Health aspects, Zidovudine, Reverse transcriptase inhibitors, Clinical report

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