Effect of ACAT inhibition on the progression of coronary artherosclerosis

Article Abstract:

The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) Inhibitors was found to have antiatherosclerotic effects on some animal models. When ACAT inhibitor pactimibe was tested on 408 patients with coronary disease, it was found that ACAT inhibitor did not improve the primary efficacy variable (percent atheroma volume) and adversely affected two major secondary efficacy measures assessed by intravascular untrasonography.

Care and treatment, Development and progression, Atherosclerosis, Acetyl coenzyme A

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Nitroprusside in critically ill patients with left ventricular dysfunction and aortic stenosis

Article Abstract:

The drug nitroprusside may improve heart function in patients with severe aortic stenosis and heart failure while they wait for an aortic valve replacement, according to a study of 25 patients. Aortic stenosis occurs when the aortic valve in the heart becomes stiff and no longer functions properly. Nitroprusside belongs to a group of drugs called vasodilators because they dilate blood vessels.

Evaluation, Drug therapy, Aortic valve stenosis, Sodium nitroferricyanide, Nitroprusside

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Statin therapy, LDL cholesterol, C-reactive protein and coronary artery disease

Article Abstract:

The reduced rate of progression of atherosclerosis associated with intensive Statin treatment is significantly related to greater reductions in the levels of both atherogenic lipoproteins and C-reactive protein (CRP). Statins have a wide range of biologic effects in addition to lipid lowering, including reducations in the levels of CRP.

Patient outcomes, Risk factors, Coronary heart disease, C-reactive protein, Statins

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