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Effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401

Article Abstract:

HIV-infected drug addicts who are on methadone maintenance can take normal doses of the protease inhibitors ritonavir and saquinavir. The drugs affect the metabolism of methadone, but only the S form, which is metabolically inactive.

Author: Flexner, Charles, Gerber, John G., Rosenkranz, Susan, Segal, Yoninah, Aberg, Judith, D'Amico, Ronald, Mildvan, Donna, Gulick, Roy, Hughes, Valery, Aweeka, Francesca, Hsu, Ann, Gal, Joseph
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
Physiological aspects, Methadone maintenance, Drug metabolism

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Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Results of AIDS clinical trials group 5108 study

Article Abstract:

An open label trial was conducted to assess the drug-drug interaction of efavirenz (EFV) used in combination with simvastatin (SIM), astorvastatin (ATR) or pravastatin (PRA). EFV when administered with SIM, ATR, or PRA can result in significant induction of stain metabolism.

Author: Gerber, John G., Segal, Yoninah, Aberg, Judith A., Rosenkranz, Susan L., Alston, Beverly L., Brobst, Susan W., Fichtenbaum, Carl J., Vega, Jose M., Amy Yang
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
United States, Simvastatin, Efavirenz (Medication)

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Beneficial pharmacokinetic interaction between atazanavir and lopinavir/ritonavir

Article Abstract:

The steady-state pharmacokinetics (PK) interactions between atazanavir (ATV), ritonavir (RTV) and lopinavir (LPV) when coadministered at various doses are determined. An appropriate PK profile for ATV and LPV was indicated by the combination of ATV at a dose of 300 mg once daily plus LPV/r at a dose of 400/100 mg twice daily.

Author: Flexner, Charles, Barditch-Crovo, Patricia, Fuchs, Edward, Parsons, Teresa, Carson, Kathryn, Pham, Paul A., Vasist, Lakshmi, Agarwala, Sangeeta
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
Clinical report, Atazanavir

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Subjects list: Health aspects, Ritonavir, HIV infection, Drug therapy, HIV infections, Dosage and administration, Drug therapy, Combination, Combination drug therapy
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