Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis

Article Abstract:

A multicenter, randomized, double-blind, prospective study of 1255 subjects with type 2 diabetes mellitus receiving maintenance hemodialysis who are randomly assigned to receive 20 mg of atorvastatin per day or matching placebo is presented. The finding indicate that atorvastatin has no statistically significant effect on the composite primary end point of cardiovascular death, nonfatal myocardial infraction, and stroke in patients with diabetes receiving hemodialysis.

United Kingdom, Type 2 diabetes, Dosage and administration, Hemodialysis patients, Atorvastatin

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Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency

Article Abstract:

Benazepril, an angiotensin-converting-enzyme inhibitor, may prevent disease progression in patients with kidney failure. In a three year clinical trial of patients with renal insufficiency from a variety of causes, 300 patients were treated with benazepril and 283 received a placebo. For patients treated with benazepril, reduction of the risk of reaching the primary endpoint of kidney function at three years was 71% for those with mild insufficiency, 46% for those with moderate insufficiency and 53% overall. Although benazepril provided no benefit for patients suffering from polycystic kidney disease, it reduced risk for male patients, patients with glomerular diseases, patients with base-line proteinuria greater than 1g/day, patients with diabetic neuropathies, and patients with insufficiency from unknown causes.

Evaluation, ACE inhibitors, Angiotensin converting enzyme inhibitors, Antihypertensive drugs, Antihypertensive agents, Chronic kidney failure

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