Prophylactic Fluconazole in Liver Transplant Recipients A Randomized, Double-Blind, Placebo-Controlled Trial

Article Abstract:

Giving liver transplant recipients the anti-fungal drug fluconazole can prevent fungal infection. Most organ transplant recipients must take immunosuppressive drugs to prevent their immune system from rejecting the organ. But this leaves them susceptible to infection. Researchers randomly assigned 212 liver transplant recipients to take fluconazole or a placebo. Fluconazole substantially reduced the rate of fungal infections, as well as death from fungal infections. However, it increased blood levels of cyclosporine, which could increase the rate of side effects from this immunosuppressive drug.

Evaluation, Prevention, Diseases, Organ transplant recipients, Liver, Liver transplantation, Mycoses, Fluconazole

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Effect of Nasogastric Tube Size on Gastroesophageal Reflux and Microaspiration in Intubated Patients

Article Abstract:

Small nasogastric tubes do not appear to prevent aspiration of stomach contents into the lungs or gastric reflux into the esophagus. Nasogastric tubes are placed thorough the nose and into the stomach so stomach contents can be suctioned. Researchers instilled radioactive solution in the stomachs of 17 patients with nasogastric tubes undergoing ventilator-assisted breathing. The subsequent radiation counts in the throat and trachea were not influenced by the size of the nasogastric tube.

United States, Stomach, Gastrointestinal intubation

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