Emergence of vancomycin resistance in Staphylococcus aureus

Article Abstract:

Two case reports illustrate that some strains of Staphylococcus (S.) aureus in the US have become resistant to the antibiotic vancomycin. Because this bacterium is resistant to other antibiotics, including methicillin, vancomycin is the only effective treatment. The two patients were both diabetics and both had infections with methicillin-resistant S. aureus. After 18 weeks of treatment with vancomycin, the bacterium acquired resistance to vancomycin. Although the infection was eventually eradicated, both patients died. These are the first known cases of vancomycin-resistant S. aureus in the US.

Health aspects, Identification and classification

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Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene

Article Abstract:

Doctors describe one of the first US cases of vancomycin-resistant Staphylococcus aureus in a 40-year-old Michigan woman. Vancomycin is the only antibiotic that is always effective for staph infections. The bacterium was found to have a gene called the vanA gene, which occurs in enterococci but has never before been found in Staphylococcus aureus.

Michigan, Demographic aspects, Drug therapy, Staphylococcal infections

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A clone of methicillin-resistant Staphylococcus aureus among professional football players

Article Abstract:

A retrospective cohort study and nasal-swab survey of 84 St. Louis Rams football players and staff members is conducted. Staphylococcus aureus recovered from wound, nasal and environmental cultures are assessed by means of pulsed-field gel electrophoresis and typing for resistance and toxin genes.

United States, Methods, Observations, Dosage and administration, Cohort analysis, Methicillin

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