Endocannabinoids acting at vascular CB (sub)1 receptors mediate the vasodilated state in advanced liver cirrhosis

Article Abstract:

Advanced cirrhosis has been shown to be associated with low blood pressure, which can be elevated by the CB1 receptor antagonist SR141716A. Cirrhotic human livers have displayed a three-fold increase in CB1 receptors, possibly mediated by an endocannabinoid that acts at these sites.

Germany, Statistical Data Included

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Cannabinoids cool the intestine

Article Abstract:

Motility and secretion in the intestine are provided by cannabinoids. They are now assigned the additional task of curbing excessive bowel inflammation, suggesting that drugs targeting the endogenous cannabinoid system could be exploited for inflammatory bowel disease.

Intestines, Inflammatory bowel diseases

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Cannabinoids hurt, heal in cirrhosis

Article Abstract:

A new molecular target for antifibrotic treatment, the [CB.sub.1] cannabinoid receptor is identified. The [CB.sub.1] receptor was originally discovered as the brain receptor for [delta.sup.9]-tetrahydrocannabinol (THC), the psychoactive component of marijuana, and for the subsequently identified endogenous ligands, arachidonyl ethanolamide and 2-arachidonoylglycerol [(2-AG).sup.3].

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