Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype

Article Abstract:

Issues related to the finding that endothelial leukocyte adhesion molecule-1 (ELAM-1) is a marker for the vasculature atherosclerotic plaque related to glaucoma are examined. Topics include the presence of ELAM-1 on trabecular meshwork (TM) cells, the nature of ELAM-1 expression, and the role of interleukin -1 in the aqueous outflow.

Statistical Data Included, Diseases, Glaucoma, Aqueous humor

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Ultrahigh-resolution ophthalmic optical coherence tomography

Article Abstract:

This article discusses an innovative technology for optical coherence tomography that allows for non-invasive in vivo, ultrahigh-resolution imaging of corneal and retinal morphology. The use of this technology to visualize retinal pathology is addressed.

Innovations, Equipment and supplies, Retina, Cornea, Ophthalmology, Optical tomography

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Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation

Article Abstract:

Mass spectroscopy-based proteomics is used to detect 117 proteins in human vitreous and elevated levels of extracellular carbonic anhydrase-I (CA-I) in vitreous from individuals with diabetic retinopathy. The inhibition of extracellular CA-I and kallikrein-mediated innate inflammation might provide new therapeutic opportunities for treating the hemorrhage-induced retinal and cerebral edema.

Science & research, Health aspects, Diabetic retinopathy, Spectra, Carbonic anhydrase inhibitors, Proteomics

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