Enhanced deoxyribonucleic acid damage and repair but unchanged apoptosis in uterine leiomyomas treated with gonadotropin-releasing hormone agonist

Article Abstract:

The decrease in fibroid tumor volume seen in women treated with gonadotropin-releasing hormone therapy appears to be due to damage sustained within the cells and not to programmed cell death events. Fibroid tissue samples were analyzed and tumor volume determined in 15 surgical patients pretreated with gonadotropin-releasing hormone therapy and 44 untreated surgical patients. Cell nuclear antigen expression was increased in pretreated patients, particularly among those with a positive response to treatment. There was similar evidence of programmed cell death in both patient groups.

Analysis, Physiological aspects, Cell death, DNA repair

---

Two-step gonadotropin-releasing hormone agonist treatment of uterine leiomyomas: standard-dose therapy followed by reduced-dose therapy

Article Abstract:

Long-term low doses of gonadotropin-releasing hormone (GnRH) agonists following high initial doses may be used to treat benign uterine tumors. Researchers treated 24 women with uterine leiomyomas with a high dose of the GnRH agonist triptorelin for eight weeks, then with one of three lower dosages for 18 more weeks. The high dose of triptorelin reduced the size of uterine leiomyomas, and this reduction was maintained by the subsequent low dosages. Ovarian and pituitary functions were partially restored during low dose treatment weeks, and the rate of bone loss was reduced.

Drug therapy, Dosage and administration, Uterine tumors

---

Telomere shortening in uterine leiomyomas

Article Abstract:

Uterine leiomyomas appear to undergo many cell divisions during their development. Uterine leiomyomas are benign uterine tumors that are often called fibroids. Researchers analyzed telomere length in tissue samples of uterine leiomyomas and normal uterine tissue from 51 women. Telomeres are special structures at the ends of chromosomes that get shorter each time the cell divides. The average telomere length in the tumors was much shorter than in normal uterine tissue. This indicates that the tumor cells proliferated faster than normal cells.

Measurement, Genetic aspects, Telomeres, Uterine fibroids

Similar abstracts:

• Abstracts: Stimulation of the CD2 receptor pathway induces apoptosis in human T lymphotropic virus type I-infected cell lines
• Abstracts: The significance of transvaginal ultrasonographic evaluation of the cervix in women treated with emergency cerclage
• Abstracts: Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies
• Abstracts: A tale of two sexually transmitted diseases: prevalences and predictors of chlamydia and gonorrhea in women attending Colorado family planning clinics
• Abstracts: Hospital readmission with feeding-related problems after early postpartum discharge of normal newborns. A Woman With an Extremely Premature Newborn

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.