Essential role of stromally induced hedgehog signaling in B-cell malignancies

Article Abstract:

Hedgehog ligands secreted by bone-marrow, nodal and splenic stromal cells have functioned as survival factors for malignant lymphoma and plasmacytoma cells derived from transgenic [E.sub.[mu]]-Myc mice or isolated from humans with these malignancies. The results have shown that stromally induced hedgehog signaling might provide a vital survival signal for B- and plasma-cell malignancies in vitro and in vivo.

Health aspects, Lymphocytic leukemia, Hedgehogs, Plasmacytoma, Clinical report

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Marrow to muscle, fission versus fusion

Article Abstract:

Participation of bone marrow cells in muscle regeneration results from the 'bona fide' generation of myogenic progenitors, or by fusion with the newly formed myotubes. Results from the experiments of Corbel et al. and Camargo et al. are used to deal with the issue.

Muscle regeneration

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Skeletal remodeling in health and disease

Article Abstract:

The article presents the causes of bone cells to become dysfunctional and the options available for control and treatment.

United States, Morphogenesis, Bone cells, Bone morphogenetic proteins

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