Evaluation of the Roche Cobas TaqMan and Abbott realtime extraction-quantification system for HIV-1 subtypes
Article Abstract:
The Abbott Molecular RealTime and Roche Diagnostics Cobas Taqman automated nucleic acid extraction and real-time polymerase chain reaction (PCR) amplification systems are compared for their capacity to quantify HIV RNA of various subtypes. The analysis has shown that the limitation of real-time PCR to span the entire diversity of HIV should be considered during treatment monitoring, resistance studies and clinical trials.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
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Phenotypic susceptibility to nonnucleoside inhibitors of virion-associated reverse transcriptase from different HIV types and groups
Article Abstract:
The phenotype assay based on plasma reverse trancriptase (RT) to assess HIV susceptibility to nonucleoside RT inhibitors (NNRTIs) is evaluated. This assay would be particularly useful for lager epidemiologic surveys of the natural HIV polymorphism and the potential impact of the emergence of drug resistance, particularly to nevirapine, widely used to prevent mother to child transmission.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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Age at which HIV infection can be detected in infants: Place of the Yakovlev model
Article Abstract:
The Yakovlev parametric cure rate model was used to study the age at which HIV-I infection could be detected in nonbreasted infants and the independent predictors of transmission. Comparison of observed and predicted delays to positivity revealed the best representation of the age at which HIV becomes detectable among 8 Yakovlev models.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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