Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

Article Abstract:

The proteases tryptase and trypsin stimulate proteinase-activated receptor 2 (PAR2) on sensory nerves. The nerves then release pro-inflammatory neuropeptides such as calcitonin gene-related peptide and substance P.

Physiological aspects, Inflammation, Inflammation mediators, Sensory receptors

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Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway

Article Abstract:

Research has disclosed a new nociceptive pathway that indicates a direct role for proteinases and their receptors in the mechanism of pain transmission. The key finding in this study shows that neurokinin-1 receptor expressed hyperalgesia has been induced by proteinase-activated receptor-2.

Statistical Data Included, Analysis, Pain, Medical research, G proteins

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Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions

Article Abstract:

The studies showed that protease activated receptor 2 (PAR-2) expression is enhanced in human coronary atherosclerotic lesions from humans with no classic risk factors for atherosclerosis. The pharmacological study establishes whether modulation of PAR-2 represents a possible therapeutic target for controlling the vascular response injury.

Science & research, Diagnosis, Coronary heart disease, Protease inhibitors

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