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Excision margins in high-risk malignant melanoma

Article Abstract:

A random clinical trial is conducted to compare one and three centimeter margins of excision for cutaneous melanoma. It is found that a 1-cm margin of excision for melanoma with a poor prognosis is associated with a significantly greater risk of regional recurrence than is a 3-cm margin, but with a similar overall survival rate.

Author: Cook, Martin, Bliss, Judith M., Thomas, J. Meirion, Newton-Bishop, Julia, Theaker, Jeffery, Fallowfield, Mary, A'Hern, Roger, O'Neill, Trevor, Coombes, Gill, Ruka, Wlodek, Timmons, Michael, Evans, Judy
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Evaluation, Cancer, Melanoma, Excision (Surgery), Cancer recurrence

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A pooled analysis of bone marrow micrometastasis in breast cancer

Article Abstract:

The prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer was assessed by means of a pooled analysis. The presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer is associated with a poor prognosis.

Author: Braun, Stephan, Pantel, Klaus, Janni, Wolfgang, Gebauer, Gerhard, Solomayer, Erich-Franz, Diel, Ingo J., Marth, Christian, Fehm, Tanja, Coombes, R. Charles, Vogl, Florian D., Naume, Bjorn, Osborne, Michael P., Schimok, Gunter, Gerber, Bernd, Pierga, Jean-Yves, Oruzio, Daniel, Wiedswang, Gro, Strobl, Barbaba, Kundt, Gunther, George Y.C. Wong, Bliss, Judith, Vincent-Salomon, Anne
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
United States, Diagnosis, Prognosis, Breast cancer, Bone marrow

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Subjects list: Research
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