Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Article Abstract:
Interleukin-8 is present in higher amounts in uterine fibroids, leading researchers to believe that it may be involved in stimulating these benign tumors. An antibody that blocks interleukin-8 also prevents cell proliferation in the tumors.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma
Article Abstract:
Transforming growth factor-beta 1 can stimulate the growth of uterine fibroids, according to a study of 28 women who had a hysterectomy. An analysis of uterine tissue samples found that the amount of transforming growth factor-beta1 was higher during the second stage of the menstrual cycle when ovulation occurs. This indicates that the production of transforming growth factor-beta1 may be stimulated by estrogen.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2003
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The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model
Article Abstract:
Monocyte chemotactic protein 1 appears to be involved in the formation of adhesions in the peritoneum. Adhesions sometimes occur at the site of surgical abdominal incisions. Researchers injured the peritoneum of 39 mice and tested tissue samples for the presence of monocyte chemotactic protein 1. This protein attracts immune cells called monocytes to the site of an injury. Most of the mice developed adhesions and the level of monocyte chemotactic protein 1 increased within 48 hours of the injury. Giving the mice an antibody to the protein reduced the formation of adhesions.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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