PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

Article Abstract:

This article analyzes the functions of peroxisome proliferator-activated receptor-gamma (PPAR) in macrophages, and also studies how the nuclear receptor is targeted by the thiazolidinedione set of antidiabetic drugs. Findings suggest that PPAR-gamma is not essential to, nor impacts, the development of macrophages, yet it is important to the regulation of the receptor CD36.

Statistical Data Included, Genetic aspects, Macrophages, Genetic regulation, Peroxisomes, Thiazolidinediones

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Muscle-specific Pparg deletion causes insulin resistance

Article Abstract:

A strain of mice with muscle-specific deletion of Pparg, the gene encoding PPAR-delta, is developed by using Cre-loxP gene targeting system. The findings indicated that muscle PPAR-delta expression play crucial role in skeletal muscle insulin sensitivity and Thiazolidinediones (TZD) action and may exert indirect effects on insulin action in adipose tissue and liver.

Muscles, Animal experimentation, Insulin resistance, Genetic code, Skeletal muscle

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PPARs and the complex journey to obesity

Article Abstract:

The 3 lipid-sensing peroxisome proliferator-activated receptors, PPAR-alpha, PPAR-gamma, PPAR-delta, regulate diverse aspects of lipid and glucose homeostasis. Link between glucose and lipid metabolism is presented with the role of PPARs as bonafide therapeutic targets.

Homeostasis

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• Abstracts: PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

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