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The role of PPAR-gamma in macrophage differentiation and cholesterol uptake

Article Abstract:

Research presented concerns the role of peroxisome proliferator-activated receptor-gamma, a ligand-dependant transcription factor, in the regulation of macrophage functions. Topics addressed include myeloid development, cell receptor expression, and macrophage foam-cell formation.

Author: Spiegelman, Bruce M., Rosen, Evan D., Altshuler, David, Moore, Katheryn J., Fitzgerald, Michael L., Randow, Felix, Andersson, Lorna P., Milstone, David, Mortensen, Richard M., Freeman, Mason W.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Genetic transcription, Transcription (Genetics), Cell differentiation, Cellular control mechanisms, Cell regulation

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PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

Article Abstract:

Research presented concerns the expression of peroxisome proliferator-activated receptors (PPAR)- alpha and gamma in human macrophage cells. Researchers study the role of PPAR-activators in foam cell formation and cholesterol metabolism, as well as the regulation of the ABCA1 pathway in patients with Tangier disease.

Author: Chinetti, Giulia, Lestavel, Sophie, Bocher, Virginie, Remaley, Alan T., Neve, Bernadette, Torra, Ines Pineda, Teissier, Elisabeth, Minnich, ANne, Jaye, Michael, Duverger, Nicolas, Brewer, H. Bryan, Fruchart, Jean-Charles, Clavey, Veronique, Staels, Bart
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Hypolipoproteinemia

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

Article Abstract:

Atherosclerotic lesion development in myeloid differentiation protein-88 (MYD88)-null mice is examined. Findings link elevated serum lipid levels to proinflammatory signaling cascade that is also engaged by microbial pathogens.

Author: Lee, Melinda A., Freeman, Mason W., Moore, Kathryn J., Bjorkbacka, Harry, Koehn, Staphanie, Halmen, Kristen, Golenbock, Douglas T., Kunjathoor, Vidya V., Ordija, Christine M., Means, Terry, Luster, Andrey D.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Science & research, Blood lipids, Atherosclerosis

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Subjects list: Research, United States, Macrophages, Genetic regulation, Peroxisomes, Cholesterol metabolism
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