Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysis

Article Abstract:

Collections of tissue taken from the lymphatic tissues around the eye, salivary glands, breast and thyroid of 16 patients were studied for the presence of a group of surface proteins, the presence of Epstein-Barr virus, and gene rearrangement. All of these samples were classified as benign (noncancerous) lymphoid hyperplasia. None of the samples showed the presence of Epstein-Barr virus. There were indications of genetic changes in the tissue samples but there was no discernable pattern. Two patients ultimately developed a malignant lymphoma (a cancer) in locations that were outside their lymph nodes. None of the remaining patients developed cancers during a two-and-a-half year follow-up period. The results suggest that masses of lymphoid tissue outside the lymph nodes which are classified as benign frequently contain within the cell population a wide range of abnormalities, including cells which are clearly malignant.

Genetic aspects, Lymphoproliferative disorders, Immunoproliferative disorders, B cells

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Development and characterisation of T lymphocyte lines from human small intestinal biopsies

Article Abstract:

T lymphocyte lines were developed from tissue samples from human small intestines obtained during gastroduodenoscopy, a method of performing visual examination of the stomach and duodenum. T lymphocytes are a type of white blood cell. Different substances caused these T cell lines to secrete interleukin-2 (IL-2), a protein factor produced by T cells in response to antigenic or mitogenic stimulation. (IL-2, which seems to produce interferon and is used as an anticancer drug, was formerly called T Cell Growth Factor.) Sufficient numbers of small intestinal lymphoid cells for study were previously available only from patients undergoing surgery of the small bowel. The ability to isolate and grow tissue cultures of human small intestinal T lymphocytes from intestinal biopsies, obtained during surgery by an instrument called a gastroscope, provides an important new tool for studies.

Growth, T cells, Cell lines, Interleukin-2, Intestine, Small, Small intestine

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Sezary cell morphology induced in peripheral blood lymphocytes: re-evaluation

Article Abstract:

In some forms of leukemia, large distinctive cells are found which have conspicuously notched or indented nuclei; these cells are called Sezary cells. This study attempts to produce a model of the Sezary cell by treating the lymphocytes, or white blood cells, of six healthy volunteers with various agents. The agents used in the study included phytohemagglutinin and concanavalin A; some lymphocytes were also placed in culture (co-cultivated) with human epidermal cells. The cells were examined by electron microscopy for changes in their anatomy. Although some cells from all experimental groups showed cells with mild to moderate changes in their nuclear shape, no cells were found which could be classified as Sezary cells. Neither stimulation with various agents, nor co-cultivation could convert normal peripheral blood lymphocytes to Sezary cells in vitro.

Abnormalities, Cell differentiation, Cell nuclei, Cell nucleus

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