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Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection

Article Abstract:

HIV patients with progressive multifocal leukoencephalopathy do not appear to benefit from the drug cytabarine or the typical drugs used to treat AIDS. Progressive multifocal leukoencephalopathy is a viral infection of the brain that is enhanced by prolonged immunosuppression. Researchers randomly assigned 57 HIV patients with this infection to take the AIDS drug zidovudine plus didanosine or stavudine or cytarabine administered in two different ways. Only 7 patients completed the 24-week treatment, and survival rates were similar in all three groups.

Author: Cohen, Bruce, Hollander, Harry, Hall, Colin D., McArthur, Justin, Simpson, David, Dafni, Urania, Wetherill, Patricia E., Timpone, Joseph, Clifford, David, Yainnoutsos, Constantin, Major, Eugene, Millar, Linda
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Evaluation, HIV infection, Drug therapy, HIV infections, Cytarabine

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Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy

Article Abstract:

Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab as a result of which an evaluation was conducted to determine whether PML had developed in any other treated patients. In conclusion, no cases of PML were found in patients treated with natalizumab

Author: Major, Eugene O., Clifford, David B., Radue, Ernst-Wilhelm, Yousry, Tarek A., Habil; Major, Ryschkewitsch, Caroline, Fahle, Gary, Fischer, Steven, Hou, Jean, Curfman, Blanche, Miszkiel, Katherine, Mueller-Lenke, Nicole, Sanchez, Esther, Barkhof, Frederick, Jager, Hans R.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
England, Risk factors, Natalizumab

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Subjects list: Complications and side effects, Leukoencephalopathy, Progressive multifocal, Progressive multifocal leukoencephalopathy
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