Progressive multifocal leukoencephalopathy in a patient treated with natalizumab

Article Abstract:

The clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection of the central nervous system, developed during treatment with interferon beta-1a and a selective adhesion-molecule blocker, natalizumab, is described. The patient was treated with systematic cytarabine, and it was found that after two months the patient's condition had improved.

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Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis

Article Abstract:

Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system (CNS), is associated with high rates of morbidity and mortality and occurs almost exclusively in immunocompromised patients. A trial was conducted to test the safety and efficacy of natalizumab in combination with interferon beta-1a in the treatment of relapsing-remitting multiple sclerosis.

Health aspects, Interferon beta

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Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

Article Abstract:

The relationship between natalizumab therapy and progressive multifocal leukoencephalopathy (PML), which is an opportunistic, infectious, demyelinating brain disorder associated with impaired T-cell function, is illustrated. Polymavirus replication leading to PML, which is a life threatening disorder, can occur in patients who receive natalizumab.

Crohn's disease

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