Fluorescence detection of cervical intraepithelial neoplasia for photodynamic therapy with the topical agents 5-aminolevulinic acid and benzoporphyrin-derivative monoacid ring

Article Abstract:

5-aminolevulinic acid is taken up only by abnormal cervical cells whereas benzoporphyrin-derivative monoacid ring is not. Therefore, 5-aminolevulinic acid would be a more effective photosensitizer for use in the treatment of abnormal cervical cells with phototherapy.

Usage, Cervix dysplasia, Phototherapy

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Structural and functional effects of endometrial photodynamic therapy in a rat model

Article Abstract:

Differing light dosages may produce differing effects on the uterine lining during photodynamic therapy. Photodynamic therapy uses chemicals to sensitize specific tissues to light and then exposes those tissues to laser light to destroy them. It is a promising nonsurgical technique for destroying abnormal growth of the uterine lining. Researchers exposed the uterus of 74 rats to laser light after injecting a light-sensitizing chemical. At one light dosage, connective tissue and muscle were damaged, but the lining recovered within three weeks. At a dosage 1.5 times higher, the lining was permanently destroyed.

Photochemotherapy, Endometrial hyperplasia

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Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid

Article Abstract:

Photodynamic therapy may be used to destroy abnormal endometrial tissue. Photodynamic therapy has been used in place of surgery in animals to destroy tissue with light-induced oxidation. Researchers measured the levels of photosensitizers in the uteri of 27 women undergoing hysterectomy and the length of time after instilling 5-aminolevulinic acid into the uterus before it reached maximum fluorescence. 5-aminolevulinic acid induced sufficient fluorescence in the endometrium to allow photodynamic therapy to be used. Maximum fluorescence was reached four to eight hours after the acid was instilled.

Physiological aspects, Endometrium, Photosensitizing compounds, Photosensitizing agents

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