Fluoroquinolone-modifying enzyme: A new adaptation of a common aminoglycoside acetyltransferase

Article Abstract:

Fluoroquinolones, the synthetic antimicrobial agents are being used since a long time in the fields of agriculture and medicine which are reported safe as naturally occurring antimicrobial modifying enzymes. This enzyme reduces the activity of ciprofloxacin by N-acetylation at the amino nitrogen on its piperazinyl substituent and hence proves that a single-function resistance enzyme is also capable of undermining two unrelated antimicrobial agents.

New Jersey, Quinolone Antibiotics, Usage, Quinolone antibacterial agents, Fluoroquinolones, Escherichia coli infections, Quinolones

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Diseased red blood cells topple iron balance

Article Abstract:

The blood from individuals with [beta]-thalassemia has abnormally large amounts of growth differentiation factor (GDF) 15, a cytokine that increases iron absorption by repressing a repressor of iron uptake, hepcidin. A mechanism is described that can be used for the inappropriate iron absorption in [beta]-thalassemia and as a potential new facet of iron physiology.

Iron & Other Tonics, Health aspects, Risk factors, Iron in the body, Iron (Nutrient), Thalassemia, Myostatin

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CD16 promotes Escherichia coli sepsis through an FcR[gamma] inhibitory pathway that prevents phagocytosis and facilitates inflammation

Article Abstract:

Experiments reveal the significant role of the Fc[gamma]RIII receptor, also called CD16, in the promotion of Escherichia coli sepsis through an FcR[gamma] inhibitory pathway. The process helps in the prevention of E. coli phagocytosis and enables inflammation of the cells.

Tumor necrosis factor, Phagocytosis, Tumour necrosis factor, Sepsis

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