Generation of C5a in the absence of C3: a new complement activation pathway

Article Abstract:

Acute lung inflammatory injury in wild-type and [C3.sup.-/-] mice after deposition of IgG immune complexes was of equivalent intensity and was C5a dependent, but injury was greatly attenuated in [Hc.sup.-/-] mice (Hc encodes C5). Injury in lungs of [C3.sup.-/-] mice and C5a levels in bronchoalveolar lavage (BAL) fluids from these mice were greatly reduced in the presence of antithrombin III (ATIII) or hirudin but were not reduced in similarly treated [C3?} mice.

United States, Immune complexes, Bronchoalveolar lavage, Antithrombin III

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IL-15 constraints mast cell-dependent antibacterial defences by suppressing chymase activities

Article Abstract:

The mouse cecal ligation and puncture model of sepsis is used for identifying a key factor of mast cell (MC)-dependent, innate immune defences against Gram-negative bacteria by showing that MC protease activity is regulated by interleukin-15 (IL-15). The results have identified an unexpected breach in MC-dependent innate immune defences against sepsis, thus suggesting that inhibiting intracellular IL-15 in MCs might improve the survival from sepsis.

Health aspects, Drug therapy, Mast cells, Sepsis, Interleukin-15, Clinical report

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