Genetic determinants of aggressive breast cancer

Article Abstract:

The article explains biomarker, genetic marker and the genetic determinants of the most aggressive form of breast cancer, namely inflammatory breast cancer (IBC). The overexpression, mutation and the deletion of some specific genes in human body are found to be the main factors leading to the development of the disease.

Breast cancer, Gene expression, Biological markers

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A role for JAK2 mutations in myeloproliferative diseases

Article Abstract:

The article discusses significance of the application of the JAK2 inhibitor in the treatment of the myeloproliferative disorders (MPDs). JAK2 is found to highly reduce the growth of JAK2V617F mutations, which is found to be the factor behind the development of MPDs in most of the patients.

Care and treatment, Myelofibrosis, Nonlymphoid leukemia, Myeloid leukemia, Hematopoietic stem cell disorders, Myelocytic leukemia

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Inherited mitochondrial diseases of DNA replication

Article Abstract:

The article discusses various nuclear gene mutations that lead to changes in the mitochondrial DNA (mtDNA) and causes several mitochondrial diseases in humans. These genes act as the proteins of mtDNA replication or provide the required precursors for the replication.

Eye, Mitochondrial DNA, DNA polymerases, Mitochondrial diseases, Ophthalmoplegia, Oculomotor paralysis

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