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Genomic signatures to guide the use of chemotherapeutics

Article Abstract:

In vitro drug response date was combined with microarray gene expression data to develop models that could potentially predict responses to different cytotoxic chemotherapeutic drugs. The chemotherapy responses signatures were integrated with signature of oncogenic pathway deregulation to identify new therapeutic strategies that use all available drugs.

Author: Marks, Jeffrey, Berchuck, Andrew, Nevins, Joseph R., Kelley, Michael J., Chan, Gina, Potti, Anil, Harpole, David, Dressman, Holly K., Bild, Andrea, Riedel, Richard F., Sayer, Robyn, Cragun, Janiel, Cottrill, Hope, Petersen, Rebecca, Ginsbury, Geoffrey S., Febbo, Phillip, Lancaster, Jonathan
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Gene expression

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Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice

Article Abstract:

Suramin, a polysulforated derivative of urea, is widely used as a chemotherapeutic drug and to treat infections. It is also a helpful agent to bridge periods after apoptotic acute liver failure caused by fulminant viral hepatitis or toxic liver damage.

Author: Gerbes, Alexander L., Eichhorst, Sore T., Krueger, Andreas, Muerkoster, Susanne, Fas, Stefanie C., Golks, Alexander, Krammer Peter H., Bilzer, Manfred, Opelz Christine, Schubert Louise, Gruetzner, Uwe
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Care and treatment, Risk factors, Composition, Apoptosis, Suramin sodium, Suramin

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Aurora kinases dawn as cancer drug targets

Article Abstract:

A new anticancer compound interferes with Aurora kinases, regulators of mitosis. VX-680, is an advanced drug development candidate, discovered by structure-based drug design and the molecule potently inhibits Aurora kinases in mitosis.

Author: Sausville, Edward A.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Influence, Mitosis

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Subjects list: Health aspects, Research, United States, Usage, Antineoplastic agents, Antimitotic agents
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