Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer

Article Abstract:

Mutations in the BRCA1 gene may occur in women with early breast cancer lacking a family history of the disease and a particular mutation may be common in Jewish women with the disease. Mutations in this gene have been associated with breast cancer in previous studies. Researchers analyzed the DNA from 30 women who developed breast cancer by the age of 30, and from 39 Ashkenazi Jewish women who developed breast cancer by the age of 40. BCRA1 mutations occurred in four (13%) of the 30 women with breast cancer. Among the Jewish women, eight (21%) had a mutation involving the loss of two nucleotides at position 185 of the gene.

Women, Jewish, Jewish women

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Case 28-2003: A 51-year-old premenopausal woman with newly diagnosed breast cancer and a strong family history of breast cancer

Article Abstract:

The case of a 51-year-old woman is presented who had breast cancer in both breasts and a strong family history of breast cancer. Her mother, her maternal grandmother, a first cousin, and a paternal aunt all had a history of breast cancer. Genetic tests revealed a mutation in the BRCA2 gene, which has been linked to breast cancer.

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Case 32-2007: A 62-year-old woman with a second breast cancer

Article Abstract:

The analysis presents the case-study of a 62-year-old woman, who developed breast cancer for the second time in the year 2007 after a gap of six years. The study shows that the patient landed up in such a situation because she didn't undergo adjuvant therapy the first time.

United States, Clinical report, Case study

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