HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

Article Abstract:

Research has been conducted on the virus-host interaction conserved in HIV-1 and Ebola viruses. Results indicate that factor Tsg101 which is involved in endosomal protein sorting is recruited by small conserved viral sequence motifs and that the agents mimicking these structures are the inhibitors of these lethal human pathogen replication.

Peptides, Proteins, Pathogenic microorganisms, Ebola virus

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HIV escape: there and back again

Article Abstract:

HIV mutates to avoid the pressure of the immune system and this process is balanced by the need of the virus to replicate efficiently. The reports, which examine the forces governing selection of HIV-specific cyto-toxic T lymphocytes escape variants and the ability of these variants to persist upon secondary transmission are presented.

Influence, Gene mutations, Gene mutation, Immune system

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HIV protease inhibitor apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia

Article Abstract:

Research has been conducted on the anti-retroviral therapies incorporating HIV protease inhibitors. Results indicate that protease inhibitor treatment inhibits nascent apolipoprotein B proteosomal degradation and that protease-inhibitor-associated hyperlipidemia is molecular based.

Australia, Protease inhibitors, Apolipoproteins, Hyperlipidemia

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