HIV-1-infected long-term slow progressors heterozygous for delta32-CCR5 show significantly lower plasma viral load than wild-type slow progressors
Article Abstract:
A certain type of chemokine receptor may be associated with slow progression of HIV infection to AIDS. Researchers analyzed chemokine receptor types in 70 patients with long-term symptom-free HIV infection, 61 HIV-negative people with high-risk lifestyles, and 336 healthy volunteers. The CCR5/delta32-CCR5 chemokine receptor genetic type was found in 37% of non-progressors, 26% of high-risk volunteers, and 16% of healthy people tested. Blood levels of HIV were also lower in people with the characteristic chemokine receptor genetic profile.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Stavudine versus zidovudine and the development of lipodystrophy
Article Abstract:
About half of all HIV patients who are taking highly active antiretroviral therapy (HAART) will develop abnormal fat metabolism regardless of whether they are taking zidovudine or stavudine. However, patients whose cholesterol levels were over 200 at the beginning of treatment are more likely to develop abnormal fat metabolism than those with normal cholesterol levels.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Alterations of apolipoprotein B metabolism in HIV-infected patients with antiretroviral combination therapy
Article Abstract:
Some AIDS drugs may cause unhealthy changes in blood lipids that can increase a patient's risk of cardiovascular disease. The most common change is an increase in blood levels of triglycerides.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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