Cross-sectional studies in AIDS pathogenesis: how far can they mislead us?

Article Abstract:

Cross-sectional studies of the AIDS epidemic may produce very misleading results as the epidemic worsens. Cross-sectional studies examine a group of people at a specific point in time, in contrast to longitudinal studies, which follow the group over time. Researchers used a modeling process to determine the effect of a cross-sectional study on three variables: one associated with the progression to AIDS, one associated with the degree of immunosuppression and one associated with both. The results show that these variables do not always accurately reflect the disease as the epidemic unfolds.

Models, Analysis, Medical research, AIDS (Disease)

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Gender differences in virologic response to treatment in an HIV-positive population: a cohort study

Article Abstract:

Women with HIV infection may respond more quickly to AIDS drugs than men with HIV infection, according to a study of 366 men and 91 women with HIV infection. The women achieved viral blood levels of 500 copies per milliliter or less faster than the men. Nevertheless, over half the men and women did not achieve this level of viral suppression.

Demographic aspects, Sex differences, Viremia

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Regional changes over time in initial virologic response rates to across Europe

Article Abstract:

Virologic response six to twelve months after starting combination antiretroviral therapy (cART) is analyzed in antiretroviral-naive EuroSIDA patients. Improvements over time are observed, suggesting that so far, the effect of primary resistance has not been of sufficient magnitude to prevent increasing suppression rates.

Europe, Science & research, Prevention, Antiviral agents, Drug therapy, Combination, Combination drug therapy, Antiretroviral agents, Clinical report

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