HIV-1 protease inhibitors: a review for clinicians

Article Abstract:

Protease inhibitors appear to forestall the development of AIDs in people with HIV infection. Protease inhibitors are a new class of drug that have a different action on HIV than reverse transcriptase inhibitors such as zidovudine. A review of the research on protease inhibitors revealed that ritonavir, indinavir and nelfinavir can effectively reduce blood levels of HIV and increase CD4+ T cell levels. Saquinavir appears to be less effective. All protease inhibitors work best when combined with reverse transcriptase inhibitors. Some individuals may become resistant to these drugs.

Evaluation, Prevention, Drug therapy, Protease inhibitors, AIDS (Disease)

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Acute human immunodeficiency virus type 1 infection

Article Abstract:

HIV infection must be detected as early as possible so that immediate treatment can begin. The infection often begins as a flu-like illness with fever, fatigue, muscle and joint pain, rash, headache and enlarged lymph nodes. Most tests detect antibodies to the virus, which takes 22 to 27 days. The only test that can detect the virus sooner is a blood or plasma p24 antigen test. Treatment with two reverse transcriptase inhibitors and a protease inhibitor may suppress viral reproduction for as long as the drugs are taken.

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Evaluation of HIV-1 Immunogen, an Immunologic Modifier, Administered to Patients Infected With HIV Having 300 to 549 X [10.sup.6]/L CD4 Cell Counts: A Randomized Controlled Trial

Article Abstract:

Intramuscular injections of Immunogen do not appear to improve survival rates in HIV patients, according to a study of 2,527 patients. Immunogen is an inactivated form of HIV which was created in an effort to stimulate the immune system.

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