HIV-specific antibodies but not T-cell responses are associated with protection in seronegative partners of HIV-1 infected individuals in Cambodia

Article Abstract:

The analyses of humoral and T-cell immune responses, in vitro susceptibility to HIV-1 infection, and B-chemokine production in a group of EU partners of HIV-1 infected individuals in a Cambodian population were carried out to identify factors protecting against HIV-1 infection. The contrast between the presence of HIV-specific lgA and the lack of detectable T-cell responses in peripheral blood from EUs supports the hypothesis that the induction of mucosal humoral responses might play a main role in conferring protection to sexually exposed individuals.

Science & research, Cambodia, Care and treatment, Research, T cells

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HIV incidence and factors contributed to retention in a 12-month follow-up study of injection drug users in Sichuan province, China

Article Abstract:

HIV-1 seroconversion and subtype are evaluated and factors associated with cohort retention are analyzed for subjects' baseline sociodemographic and behavioral characteristics in a 12-month follow-up study of injection drug users (IDUs). No drug-using or sexual behaviors are found to be associated with retention and the results suggest that HIV is spreading rapidly to more geographic areas along drug trafficking routes in China.

China, Drug therapy, Drug traffic, Drug dealing

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