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Plugging the leaks

Article Abstract:

Research has been conducted on the vascular leakage in inflammation which is dependent on neutrophils. The development of the anti-inflammatory drugs with a new action mechanism based on the permeability-enhancing activity produced by neutrophils is described.

Author: Ley, Klaus
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Anti-inflammatory drugs, Anti-inflammatory agents

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Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability

Article Abstract:

Research has been conducted on the polymorphonuclear leukocyte. The involvement of the paracrine mechanism in neutrophil-evoked alteration in endothelial barrier function has been investigated and the results are reported.

Author: Gautam, Narinder, Olofsson, A. Maria, Herwald, Heiko, Iversen, Lars F., Lundgren-Akerlund, Evy, Hedqvist, Per, Afros, Karl -E., Flodgaard, Hans, Lindbom, Lennart
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Denmark, Sweden, Carrier proteins, Transport proteins, Endothelium, Heparin, Leukocytes, White blood cells

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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

Article Abstract:

Research shows that formation of atherosclerotic lesions by the circulating activated platelets and platelet-leukocyte/monocyte aggregates is due to the platelet P-selectin-mediated delivery of platelet-derived proinflammatory factors onto monocytes/leukocytes and the blood vessel wall in apolipoprotein E deficient mice.

Author: Littman, Dan R., Jung, Steffen, Ley, Klaus, Smith, David F., Huo, Yuqing, Schober, Andreas, Forlow, S. Bradley, Hyman, Matthew Craig, Weber, Christian
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Germany, Causes of, Influence, Inflammation mediators, Apolipoproteins, Blood platelets, Atherosclerosis

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Subjects list: United States, Analysis, Physiological aspects, Medical research, Neutrophils, Permeability
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