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High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide sythase

Article Abstract:

High-density lipoprotein (HDL) protects against atherosclerosis by mediation of scavenger receptor-BI and by activating endothelial nitric oxide synthase in a process that requires apolipoprotein ApoA-1. This also increases nitric oxide production, which might be an important factor in the atheroprotective properties of ApoA-1 and HDL.

Author: Yuhanna, Ivan S., Zhu, Yan, Cox, Blair E., Hahner, Lisa D., Osborne-Lawrence, Sherri, Lu, Ping, Marcel, Yves L., Anderson, Richard G.W., Mendelsohn, Michael E., Hobbs, Helen H., Shaul, Philip W.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
United States, Canada, Statistical Data Included, Cardiovascular diseases, Protein binding, Nitric oxide, High density lipoproteins

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Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

Article Abstract:

The role of regulator of G-protein signaling-2 (RGS-2), a GTPase for Gq, as an important cGMP-dependent protein kinase-interacting-proteins (GKIPs) and substrate of cGMP-dependent protein kinase I-alpha (PKGI-alpha) is investigated. Its effect on nitric oxide (NO) action and systemic blood pressure is also studied.

Author: Siderovski, David P., Zhu, Yan, Lu, Ping, Mendelsohn, Michael E., Aronovitz, Mark, Karas, Richard H., Tang, Mary, Wang, Guang, Heximer, Scott P., Kaltenbronn, Kevin M., Blumer, Kendall J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Influence, Muscle contraction, Blood pressure, G proteins, Protein research, Muscle relaxation

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27-hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Article Abstract:

Studies conducted about 27-hydroxycholesterol (27HC), a cholesterol metabolite found in atherosclerotic lesions is presented. 27HC is the major factor contributing to the loss of estrogen protection from vascular disease.

Author: Mangelsdorf, David J., Yuhanna, Ivan S., Shaul, Philip W., Cummins, Carolyn L., Umetani, Michihisa, Korach, Kenneth S., Domoto, Hideharu, Gormley, Andrew K., Javitt, Norman B.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Health aspects, Estrogen, Estrogen receptors, Blood circulation disorders, Vascular diseases

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Subjects list: Research, Causes of, Atherosclerosis
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