High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Article Abstract:

Erythroblast transcriptome profiles from healthy, nonthalassemic donors are examined in order to test if the accumulation of iron in the absence of blood transfusions might result from inappropriate suppression of the iron-regulating peptide hepcidin. The results have shown that the growth differentiation factor 15 (GDF15) overexpression arising from an expanded erythroid compartment has contributed to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

Health aspects, Gene expression, Thalassemia, Iron proteins

---

Progress and potential for regenerative medicine

Article Abstract:

Regenerative medicine focuses on new therapies aimed to replace or restore lost, damaged, or aging cells in the human body to restore function and hence collaborative efforts are on in nonmammalian and human development, genetics, and tissue engineering. The development in limb regeneration, fetal wound healing, stem cell biology, and tissue engineering as a foundation for developing new clinical therapies to enhance and stimulate human regeneration, is reviewed.

United States, Technology application, Regeneration (Biology), Tissue engineering, Stem cell research

---

Similar abstracts:

• Abstracts: Virucides in prevention of HIV infection: research priorities. Genomic homogeneity of the AHU/IA-1,2 phenotype of Neisseria gonorrhoeae during its disappearance from an urban population
• Abstracts: Hemodynamic effects of sildenafil in men with severe coronary artery disease. Prevention of Cardiovascular events after Percutaneous Coronary Intervention
• Abstracts: Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.