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Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

Article Abstract:

Affymetrix HG-U133A microarrays are used to perform gene-expression profiling of large-airway epithelian cell brushings obtained from current and former smokers who underwent flexible bronchoscopy, as a diagnostic study of clinical suspicion of lung cancer. The results have shown that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, owing to a cancer-specific airway-wide response to cigarette smoke.

Author: Keane, Joseph, Gang Liu, Anderson, Timothy, Spira, Avrum, Beane, Jennifer E., Shah, Vishal, Steiling, Katrina, Schembri, Frank, Gilman, Sean, Dumas, Yves-Martine, Calner, Paul, Sebastiani, Paola, Sridhar, Sriram, Beamis, John, Lamb, Carla, Gerry, Norman, Lenburg, Marc E., Brody, Jerome S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Risk factors, Genetic aspects, Smokers, Gene expression, Lung cancer

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Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1

Article Abstract:

A study was conducted to examine the interactions of Staphylococcus aureus protein A and airway epithelial cells. The result shows that protein A has a chief role in the induction of pneumonia and the recruitment of polymorphonuclear leukocytes (PMNs) into the airway through activation of TNFR1, a receptor for tumor-necrosis factor-alpha (TNF-alpha).

Author: Gomez, Marisa, Lee, Aram, Reddy, Bharat, Muir, Amanda, Soong, Grace, Pitt, Allyson, Cheung, Ambrose, Prince, Alice
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Staphylococcus aureus, Neutrophils

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A GABAergic system in airway epithelium is essential for mucus overproduction in asthma

Article Abstract:

The role of airway epithelial cells in the production of mucus due to allergic reactions in asthma was studied and options for asthma management presented.

Author: O'Byrne, Paul M., Mingyao Liu, Kelly, Margaret M., Yun-Yan Xiang, Shuhe Wang, Hirota, Jeremy A., Li Jingxin, William Ju, Yijun Fan, Bin Ye, Orser, Beverly, Wei-Yang Lu, Inman, Mark D.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
United States, Asthma, GABA

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Subjects list: Health aspects, Research, Causes of, Epithelial cells
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