High-risk behavior and potential transmission of drug-resistant HIV among injection drug users

Article Abstract:

The prevalence of drug resistance among injection drug users (IDU) is reported and indicates a growing public health concern and use of prevention programs. Improving antiretroviral therapy (ART) adherence, appropriate prescribing of highly active antiretroviral therapy (HAART) regimens to prevent or overcome resistance, and risk reduction counseling is considered the most important ways to reduce transmission of drug-resistant HIV.

Diagnosis

---

Lack of antagonism between abacavir, lamivudine, and tenofovir against wild-type and drug-resistant HIV-1

Article Abstract:

Tenofovir and lamivudine were tested against wild-type and drug-resistant HIV-1 in vitro using peripheral blood mononulcear cells and MT-4 cells to study antagonistic drug-drug interactions combinations of abacavir. The results revealed that antagonism might be detectable in the presence of relevant mutations that were not detectable with wild-type virus.

Care and treatment, Risk factors, Lamivudine, Tenofovir

---

Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy

Article Abstract:

Studies are conducted to determine the persistence of drug resistant virus in peripheral blood mononuclear cells (PBMCs) after long-term highly active antiretroviral therapy. Data shows that virus variant that is able to replicate for a certain period enter the latent reservoir and remain archived in the PBMCs for a long period.

Similar abstracts:

• Abstracts: Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen into 1 and 2 clinical trials
• Abstracts: Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. part 2 Novel therapies based on mechanisms of HIV-1 cell entry
• Abstracts: Prevention of HIV transmission through Brest-feeding: strengthening the research agenda. Psychomotor slowing in Hepatitis C and HIV infection
• Abstracts: Use of antiretroviral drugs to prevent HIV-1 transmission through breast-feeding: from animal studies to randomized clinical trials
• Abstracts: Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.