Hip involvement in early rheumatoid arthritis

Article Abstract:

Ultrasound studies may identify hip joint deterioration before the onset of acute symptoms in patients with rheumatoid arthritis (RA). This may allow earlier treatment so that the need for hip joint replacement can be averted. A group of 113 patients with RA were followed for at least 5 years. During that time 15 patients had 21 hip joint replacements. Increased disease activity at the beginning of the study was strongly associated with the need for hip joint replacement. Another group of 76 RA patients with a recent onset of disease underwent ultrasound imaging of their hip joints. Thirteen patients had abnormal changes on the ultrasound scan. Nine patients had abnormalities in both hips. Four of these patients had signs of hip joint destruction on a follow-up X-ray. All 13 patients had no or only mild symptoms. Conversely, six of the remaining 63 patients had mild symptoms though their scans were normal. Severe pain and damage evident on X-ray appear to be a late sign of hip joint destruction.

Evaluation, Diagnosis, Joint diseases, Diagnosis, Ultrasonic, Diagnostic ultrasonography

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Increased concentrations of bone sialoprotein in joint fluid after knee surgery

Article Abstract:

Increased concentrations of bone sialoprotein in joint fluid after knee injury may indicate joint remodeling at the cartilage-bone junction and in the underlying bone. Bone and cartilage forming cells produce bone sialoprotein at the cartilage-bone interface and within the bone growth plate. Researchers measured the bone sialoprotein concentration in joint fluid drawn from the knees of 19 healthy volunteers, 114 patients with ruptured anterior cruciate ligaments with our without tears of the kneecap cartilage, and 80 patients with kneecap injuries. Bone sialoprotein concentration was increased in the injured patients and remained increased for six months postinjury.

Injuries, Physiological aspects, Osteoarthritis, Knee, Knee injuries

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Cartilage and bone macromolecules in knee joint synovial fluid in rheumatoid arthritis: relation to development of knee or hip joint destruction

Article Abstract:

It may be possible to identify rheumatoid arthritis patients destined to have rapid joint destruction early in the process. Researchers analyzed joint fluid samples periodically taken from 18 rheumatoid arthritis patients who rapidly experienced joint destruction and 25 patients with slow degenerative processes. Early in the process in the rapid destruction group aggrecan levels were high. Aggrecan concentration decreased over time and bone sialoprotein concentrations increased. Aggrecan is a component of cartilage and thus could be released as cartilage degenerated. Bone sialoprotein would appear later as cartilage disappeared.

Joints, Abnormalities, Joints (Anatomy), Inflammation

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