How early is early? Experts debate when and how to start HIV treatment

Article Abstract:

Experts at the Eighth International Conference on AIDS urged that HIV therapy be started while the disease is still in its latency stage. Since research has shown that HIV replication is already quite extensive a few weeks after infection, some conferees felt that treatment should be begun when CD4 levels are still high - about 750, instead of 500 as currently prescribed. They also suggested utilizing drug combinations - DDI and AZT or DDC and AZT - as a primary treatment, rather than as a last resort.

HEALTH SERVICES, Zidovudine, Didanosine

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Citing loss of underground DDC, AIDS activists urge more access

Article Abstract:

AIDS activists call for Hoffmann-La Roche Inc to supply experimental HIV drug, DDC, to more patients. A Food and Drug Administration (FDA) ruling limiting access to a black market form of the antiviral led to the call for liberalizing eligibility rules on patient access. Questions over variations in the black market drug's quality and potency were at issue in the FDA ruling. Hoffman La Roche has asked for FDA approval to market DDC and AZT, and expects an answer mid-year 1992.

Laws, regulations and rules

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Panel calls for accelerated approval of AIDS drug

Article Abstract:

A Food and Drug Administration advisory panel has called for speedy approval of Hoffman-La Roche Inc's antiretroviral drug dideoxycytidine (DDC). The drug is to be approved for use only in conjunction with zidovudine (AZT) on HIV-infected patients. The recommendation was based on studies showing that this combination of drugs resulted in an increase in CD4 lymphocytes, a marker of efficacy.

Regulation of agricultural marketing, Investigations, HIV patients, Antiviral agents

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