Human T lymphotropic virus type II (HTLV-II): epidemiology, molecular properties, and clinical features of infection

Article Abstract:

Human T lymphotropic virus type II (HTLV-II) is widespread in many American Indian tribes but has also been discovered in Europe and Southeast Asia. Because it is transmitted by contaminated blood, it is also found in intravenous drug addicts. It is also transmitted sexually and in breast milk. There are two subtypes, a and b, which are 93% to 96% similar. The virus has been linked to some T cell disorders and also to a neurologic disease that resembles the disease caused by HTLV-I.

Physiological aspects, Demographic aspects, HTLV-II infections, HTLV-II (Virus)

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Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotrophic virus type I

Article Abstract:

The generation of human T-lymphotropic virus type I Tax transgenic mice is described using the Lck proximal promoter to restrict transgene expression to developing thymocytes. After the prolonged latency periods, transgenic mice developed diffuse large-cell lymphomas and leukemia with clinical, pathological and immunological features characteristic of acute adult T-cell leukemia-lymphoma, a group of T-cell malignancies caused by infection with HTLV-I.

United States, Genetic aspects, Malignant lymphomas

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Dying T cells trigger autoimmunity in HIV

Article Abstract:

Researchers have discovered that dying [CD4.sup.+] T helper cells release protein fragments that have prompted the formation of autoreactive [CD8.sup.+] T cells. Results suggested that the presence of autoreactive [CD8.sup.+] T cells might result in excessive immune activation observed in chronic HIV-1 infection.

Autoimmunity, Tumor antigens, Tumour antigens

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