Human chorionic gonadotropin directly and indirectly alters uterine arteriolar diameters in cycling rats

Article Abstract:

Uterine blood vessels may respond differently to human chorionic gonadotropin (hCG) according to the stage of menstruation. Researchers analyzed the response of uterine blood vessels to hCG in cycling rats and in rats with removed ovaries through systemic and local administration of hCG. Uterine blood vessels responded differently according to the stage of rat estrus when hCG was locally applied. Local application of hCG overrode ovarian control but systemic injection did not. Such findings may improve understanding of vascular and hormonal interactions in human pregnancy and fertility.

Menstrual cycle, Chorionic gonadotropin, Chorionic gonadotropins

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A new technique for studying the uterine microvasculature in the rat

Article Abstract:

A rat model may be useful in studying uterine micro-blood vessel structure and response to chemical stimulation. Researchers inserted a fiberoptic probe into the uterus of live anesthetized female rats and measured the response of uterine blood vessels to chemical stimulation. Uterine vessels narrowed in response to angiotensin II and phenylephrine solutions dripped over the exposed uterus. Vessels dilated in response to serotonin and acetylcholine drips. There was no vessel response in rats who had no chemical stimulation.

Observations, Microcirculation, Rats as laboratory animals, Laboratory rats

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Pregnancy-induced alterations of uterine arteriolar reactivity in the rat: observations with a new in vivo microcirculatory preparation

Article Abstract:

Researchers used video-microscopy to observe uterine blood vessels in pregnant and non-pregnant rats. This technique can be used to directly observe the response of blood vessels to various substances.

Pregnancy, Video microscopy

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