Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): A major prognostic indicator in uterine serous papillary cancer

Article Abstract:

The association of overexpression of HER2/neu oncogene with poor outcome in uterine serous papillary endometrial cancer is examined and the contribution of racial difference in the frequency of HER2/neu overexpression to the disparity in endometrial cancer survival is determined. It is found that the overexpression of HER2/neu in uterine serous papillary endometrial cancer is associated with poor outcome, occurring frequently in black women and also possibly contributing to racial disparity in survival.

Italy, Health aspects, Care and treatment, Patient outcomes, Uterine cancer, Cancer survivors, Women patients

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Retinoic acid up-regulates the expression of major histocompatibility complex molecules and adhesion/costimulation molecules (specifically, intercellular adhesion molecule ICAM-1) in human cervical cancer

Article Abstract:

Immunologic modulation through increased expression of surface antigens may account for retinoic acid's effectiveness in treating cervical cancer. Expression of major histocompatibility complex class I and intercellular adhesion molecule ICAM-1 was increased in cervical cancer cell lines following exposure to therapeutic doses of retinoic acid. Increased expression of major histocompatibility complex class I messenger ribonucleic acid occurred at the transcriptional level.

Cervical cancer, Cell adhesion molecules, Major histocompatibility complex, Tretinoin

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In vitro induction of tumor-specific human lymphocyte antigen class I-restricted CD8+ cytotoxic T lymphocytes by ovarian tumor antigen-pulsed autologous dendritic cells from patients with advanced ovarian cancer

Article Abstract:

Dendritic cells exposed to ovarian tumor tissue samples can induce the immune system to attack ovarian cancer cells. Dendritic cells are part of the immune system and they have the ability to take up tumor antigens and use them to activate the immune system against the antigen.

Ovarian cancer, Antigen presenting cells

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