Cytokines and systemic lupus erythematosus

Article Abstract:

Patients with systemic lupus erythematosus have increased levels of cytokines compared to healthy people and people with other rheumatic diseases. Different cytolines are involved depending on whether the patient has skin disease, neurological disease, or kidney disease. Cytokines are proteins produced by the immune system.

Cytokines

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Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosus

Article Abstract:

Increased levels of certain types of heat shock proteins (hsp) may occur in patients with systemic lupus erythematosus (SLE). SLE is a chronic inflammatory disease that may be caused by failure of the regulatory mechanisms of the autoimmune system. Hsp levels were measured in blood samples from 102 SLE patients and 59 healthy individuals (control group). Levels of the 90 kilodalton and the 72 kilodalton hsps were significantly higher in SLE patients than in the control group. Patients with severe active SLE had higher blood levels of the 90 kilodalton hsp than those with inactive or mildly active SLE. Concentrations of the 60 kilodalton and the 73 kilodalton hsps were similar for the two groups. Exposure to different types of stressful stimuli may cause increased production of hsps.

Heat shock proteins

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Further validation of the BILAG disease activity index in patients with systemic lupus erythematosus

Article Abstract:

Individual scores within the British Isles Lupus Assessment Group (BILAG) evaluation appear to be useful in evaluating disease activity in patients with lupus. Researchers statistically analyzed the usefulness of the BILAG compared to patients' reports of their health and blood tests among 140 patients with lupus. There were strong correlations between standard measures of disease activity and all but one of the eight parts of the BILAG assessment. There were not any significant associations between any two of the eight components within the BILAG assessment.

Development and progression

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