Focal modification of electrical conduction in the heart by viral gene transfer

Article Abstract:

Research indicates that utilizing myocardial gene transfer strategies is a feasible approach to treat common cardiac arrhythmias. Findings were based on genetically modifying the atrioventricular node via infection with an adenovirus which created a localized beta-blockade and effectively slowed heart rate without resulting in a complete heart block.

Germany, Statistical Data Included, Physiological aspects, Electrocardiography, Heart beat, Heart rate, Adenoviruses, Arrhythmia, Viral genetics

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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts

Article Abstract:

A study in which large, force-generating engineered heart tissue was created from neonatal rat heart cells was conducted. The engineered heart tissues formed thick cardiac muscle layers when implanted on myocardial infracts in immune-suppressed rats and provide evidence that large contractile cardiac tissue grafts could be constructed in vitro and survive after implantation.

Patient outcomes, Heart, Heart transplantation, Heart murmurs

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Molecular ablation of ventricular tachycardia after myocardial infarction

Article Abstract:

Focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border destroyed all ventricular arrhythmias in a porcine model. Results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.

Health aspects, Genetic aspects, Potassium channels, Ventricular tachycardia

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