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Stem cell repopulation efficiency but not pool size is governed by p27(kip1)

Article Abstract:

This article discusses the cyclin-dependent kinase inhibitor p27(kip1). The authors maintain p27 does not affect stem cell number, cell cycling, or self-renewal, as does p21, but alters progenitor proliferation and pool size.

Author: Scadden, David T., Cheng, Tao, Rodrigues, Neil, Dombkowski, David, Stier, Sebastian
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Analysis, Physiological aspects, Protein kinases, Cell research, Cytological research

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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Article Abstract:

The evidence that the vascular endothelial growth factor (VEGF) specific antibody bevacizumab has a direct and rapid antivascular effect on tumors in humans is presented. A single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients.

Author: Jain, Rakesh K., Munn, Lance L., Ryan, David P., Fischman, Alan J., Scadden, David T., Shellito, Paul C., Chen, Helen X., Sahani, Dushyant V., Lauwers, Gregory Y., Chung, Daniel C., Mino, Mari, Boucher, Yves, Kozin, Sergey V., Clark, Jeffrey W., Willet, Christopher G., Tong, Ricky T., Tomaso, Emmanuelle di, Duda, Dan G., Kalva, Sanjeeva P., Hartford, Alan C., Cohen, Kenneth S., Zhu, Andrew X., Blaszkowsky, Lawrence S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Health aspects, Colorectal cancer, Vascular endothelial growth factor

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Osteoclasts eat stem cells out of house and home

Article Abstract:

Evidence for a new participant in the endosteal niche of hematopoietic stem cells, the bone-resorbing osteoclast is presented. The osteoclast regulates hematopoiesis, and some hematopoeitic stem cells (HSCs) reside at the interface of bone and bone marrow, the endosteal surface.

Author: Scadden, David T., Purton, Louise E.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Hematopoietic agents, Osteoclasts (Biology)

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Subjects list: United States, Stem cells, Research
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