Human herpesvirus-6 and the course of human immunodeficiency virus infection

Article Abstract:

Human herpesvirus-6 (HHV-6) may accelerate the progression of AIDS in patients with HIV-1. Researchers tested blood from HIV-seropositive and HIV-seronegative patients for the presence of HHV-6 DNA and CMV DNA. HHV-6 was detected in 11 of 52 seropositive patients and 1 of 29 seronegative patients. CMV was detected in 3 of 25 seropositive patients and none of 29 seronegative patients. The researchers then closely monitored an HIV infected patient for 6 years. As the patient began to develop AIDS, his CD4 positive T cell count decreased and his HIV antigen level increased as he developed an HHV-6 infection. Thus HHV-6 may increase the multiplication of HIV-1. When the patient was treated with AZT, HHV-6 could not be detected in his blood. But when AZT treatment was stopped, HHV-6 viral DNA reappeared.

Development and progression, HIV infection, HIV infections, Herpesviruses

---

Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report

Article Abstract:

The activation of the nuclear factor-kappa B nucleoprotein may activate T-cells in synovial tissue of rheumatoid arthritic joints differently than in joints affected by other arthritic conditions. Nuclear factor-kappa B controls gene expression related to inflammatory and immune processes. Researchers tested synovial membranes and T-cells from the blood of patients with rheumatoid arthritis, spondyloarthropathies, and osteoarthritis. T-cells from rheumatoid synovium showed enhanced nuclear factor-kappa B binding, compared to T cells in the blood. This distinction was not apparent in synovium or T-cell samples from non-rheumatic arthritis patients.

Spain, Genetic aspects, Rheumatoid arthritis, Osteoarthritis, Nucleoproteins, Genetic regulation, Genetic transcription, Transcription (Genetics), Spondyloarthropathies

---

Direct quantification of HIV-1 RNA in human plasma by free solution capillary electrophoresis (FSCE)

Article Abstract:

Free solution capillary electrophoresis may be an effective alternative for measuring HIV RNA levels in blood. The technique was used on blood samples from 15 healthy volunteers and 10 people with HIV infection. Four were in the initial stage of the infection and 6 were chronically infected but asymptomatic. The 4 people with acute HIV infection had peaks on electrophoresis corresponding to HIV RNA levels of 1.08-1.71 x 10(super)8. No electrophoretic peaks were visible from samples provided by the 6 asymptomatic patients or the 15 healthy volunteers.

Usage, Measurement, HIV (Viruses), HIV, Electrophoresis, RNA, Virus replication

Similar abstracts:

• Abstracts: Risk factors for mother-to-child transmission of human immunodeficiency virus-1 infection. Culture-independent analysis of virginal microflora: The unrecognized association of Atopobium vaginae with bacterial vaginosis
• Abstracts: Pregnancy in a cohort of long-term partners of human immunodeficiency virus-seropositive hemophiliacs. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
• Abstracts: Gynecologic disease in women infected with human immunodeficiency virus type 1. Editorial

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.