Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

Article Abstract:

Transplantation of autologous human hematopoietic fetal liver [CD34.sup.+] cells into nonobese diabetic severe combined immune deficiency (NOD/SCID) mice previously implanted with human fetal thymic and liver tissues results in long-term, systemic human T-cell homeostasis. T cells in these mice generate human major histocompatibility complex class I- and class II-restricted adaptive human immune responses to Epstein-Barr virus infection and are activated by human dendritic cells to mount a potent T-cell immune response to superantigens.

Hematopoietic stem cells, Hematopoietic stem cell transplantation

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Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

Article Abstract:

The development of recombinant cell-penetrating forms of suppressor of cytokine signaling (SOCS) 3 (CP-SOCS3) for intracellular delivery to counteract staphylococcal enterotoxin B (SEB), lipopolysaccharide (LPS) and lectin concanavalin A (ConA) -induced inflammation is discussed. CP-SOCS3 reduces production of inflammatory cytokines and attenuates liver apoptosis and hemorrhagic necrosis.

Care and treatment, Staphylococcal infections, Apoptosis

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Immune privilege or inflammation: insights into the fas ligand enigma

Article Abstract:

The biological functions of Fas ligand (FasL) are examined, focusing on research that indicates it elicits both an immunological and inflammatory effect. Topics include FasL's role in transplantation and in combatting tumors; FasL expression in several cancers; a description of FasL's anti-inflammatory effects; and a history of the research involving FasL.

Statistical Data Included, Cellular immunity

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