Hyper-IgE syndrome with recurrent infections -- an autosomal dominant multisystem disorder

Article Abstract:

The hyper-IgE syndrome affects many different organs, including the teeth, skeleton, and connective tissues. This syndrome was originally described as an immune disorder characterized by excessive blood levels of the IgE antibody and recurring infections. A study of 30 patients with hyper-IgE syndrome and 70 of their relatives found that all patients older than eight years old had other symptoms besides an immune disorder. Seventy-two percent still had their primary teeth, 68% had hyperextensible joints, 76% had scoliosis, and 57% had recurring bone fractures. Ten relatives had the disorder and 6 had a milder form.

Case studies, Immunologic diseases

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Postherpetic neuralgia - pathogenesis, treatment, and prevention

Article Abstract:

The treatment of postherpetic neuralgia should be individualized to each patient. Postherpetic neuralgia is a chronic pain that occurs after an attack of herpes zoster. It is caused by a reactivation of the virus, which often remains dormant in nerves. Many painkillers such as aspirin are not effective. The best treatment appears to be lidocaine cream or gel followed by tricyclic antidepressants, transdermal electrical nerve stimulation, biofeedback and hypnosis. Acyclovir, famciclovir or valacyclovir may be used during a herpes attack to prevent the development of neuralgia. Corticosteroids may also be effective.

Care and treatment, Complications and side effects, Neuralgia, Shingles (Disease), Herpes zoster

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Somatic mutations-not just for cancer anymore

Article Abstract:

Somatic mutations can arise in discrete cell lineages early in embryonic development or during postnatal life. Although many cancers arise from single cells through the accretion of somatic mutations that afford growth and survival advantages, such mutations can also cause an autoimmune disease.

Causes of, Risk factors, Development and progression, Autoimmune diseases, Cancer, Antibody diversity

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