Is tissue plasminogen activator a threat to neurons?

Article Abstract:

Research presented concerns the use of tissue plasminogen activator (tPA), a blood clot-dissolving drug that treats victims of occlusive stroke. Physiological research suggests that tPA may adversely affect neurons by inducing neurodegeneration.

Physiological aspects, Drug therapy, Stroke (Disease), Stroke, Neurons, Tissue plasminogen activator, Thrombosis, Blood clot

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Sporadic ALS: Blame it on the editor

Article Abstract:

Evidence had proved that abnormal mRNA encoding a glutamate receptor subunit might promote sporadic amyotrophic lateral sclerosis (ALS). This abnormal RNA editing cannot explain all motor neuron loss in ALS.

Genetic aspects, Motor neurons, Amyotrophic lateral sclerosis

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Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior

Article Abstract:

A study reports that fasting upregulates the expression of huntingtin-associated protein 1(Hap 1) in the rodent hypothalamus, whereas intracerebroventricular administration of insulin downregulates Hap 1 by increasing its degradation through ubiquitination. Findings provide evidence-linking hypothalamic Hap 1 to the neurotransmitter gamma aminobutyric acid in the stimulation of feeding and suggest that this mechanism is involved in the feeding-inhibitory actions of insulin in the brain.

All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Butyric Acid, Food habits, Hypothalamus, Neurotransmitters, Chemical properties

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